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Sunday, September 7, 2025 at 7:15 AM
Cuero Hospital

The oldest pharmacy in Texas

The oldest pharmacy in Texas
Reuss Pharmacy was known as the oldest operating pharmacy in Texas, but it closed its doors for the last time Aug. 27. It opened in Cuero in 1872 in a wood building, then later moved to new brick strucure in downtown on Main Street in 1885 before moving again to a more modern building on Esplande in 1971. Photo by Sally Rodgers-Spencer

Contributing Writer

From its beginnings in a tent beside a sandy street in Indianola to its current location on the main highway through Cuero, Reuss Pharmacy has been serving Texas residents since 1845. And now, after 180 years, the company that currently owns Reuss has closed the doors for good on Wednesday, Aug. 27, at 11:00 a.m.

For decades, it was a place where locals could not only get their prescriptions filled, they could buy medical devices, medical supplies, over-thecounter medications, gifts and cards. Cueroites could count on windows being decorated for the various holidays and with Go Gobbler slogans during football season.

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